GENE XPERT OUTCOMES OF ADULT PRESUMPTIVE PULMONARY TUBERCULOSIS PATIENTS IN NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL (NAUTH) NNEWI, ANAMBRA STATE, NIGERIA.
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Abstract
Background:
Tuberculosis (TB) and drug-resistant TB are public health issues in Nigeria. Gene Xpert assay is currently used to detect TB and Multidrug-resistant/Rifampicin-resistant tuberculosis (MDR/RR-TB). This study assessed the Gene Xpert outcomes of adult presumptive pulmonary tuberculosis patients in NAUTH Nnewi, Anambra State, Nigeria.
Methodology:
A descriptive cross-sectional study was carried out among 180 adult presumptive pulmonary tuberculosis patients aged ≥ 18 years who presented to the TB centre, NAUTH Nnewi between June and September 2024. A semi-structured, interviewer-administered questionnaire was used to obtain data, while sputum samples were examined using Gene Xpert assay. Data were analyzed using SPSS version 25.
Results:
Ninety-five (52.8%) of the respondents were males, with a mean age of 40.46 ± 15.72 years. Out of the 180 sputum samples, 63 (35.0%) had Mycobacterium tuberculosis (MTB) detected using Gene Xpert assay. Among the 63 MTB-positive sputum samples, 6 (9.5%) were resistant to rifampicin, 60.3% were not resistant to rifampicin, while 30.2% were indeterminate.
Conclusion:
TB and MDR/RR-TB are public health issues in the study area. The use of improved diagnostic tests like the Gene Xpert MTB/RIF assay should be scaled up at each point of care in the State to improve case detection.
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References
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